12:56 CET
EU 1 - Cardiovascular effects after radiotherapy for breast cancer: the European MEDIRAD Project
EuroSafe Imaging Oncologic Imaging Cardiac Breast Physics in Medical Imaging
Wednesday, February 27, 08:30 - 10:00
Type of session: EuroSafe Imaging Session
Topic: EuroSafe Imaging, Oncologic Imaging, Cardiac, Breast, Physics in Medical Imaging
Moderators: A. Crijns (Groningen/NL), G. Frija (Paris/FR)

08:30
Chairpersons' introduction (part 1)
A. Crijns; Groningen/NL
Learning Objectives

1. To learn about major cardiovascular events after radiotherapy for breast cancer.
2. To understand the importance of assessing their relationship with radiation dose to cardiac substructures.
3. To appreciate the potential of imaging biomarkers for their early detection and their role in prevention strategies.

08:33
Chairpersons' introduction (part 2)
G. Frija; Paris/FR
Learning Objectives

1. To learn about major cardiovascular events after radiotherapy for breast cancer.
2. To understand the importance of assessing their relationship with radiation dose to cardiac substructures.
3. To appreciate the potential of imaging biomarkers for their early detection and their role in prevention strategies.

08:36
Overview of dose-effect relationships and their use in strategies for prevention of cardiovascular effects after radiotherapy for breast cancer
A. Crijns; Groningen/NL
Learning Objectives

1. To learn about the increased risk of various major cardiac events after incidental exposure of the heart during breast radiotherapy.
2. To understand that multivariable prediction models are needed describing the relationship between radiation dose to cardiac substructures and (early) cardiovascular effects.
3. To appreciate the role of modern cardiac imaging techniques in providing detailed information regarding early cardiovascular effects after radiotherapy.

08:52
08:57
Optimisation of multivariable prediction models for major cardiac events after radiotherapy for breast cancer
D. S. Spoor; Groningen/NL
Learning Objectives

1. To appreciate how the MEDIRAD-BRACE study will provide optimised multivariable prediction models for major cardiac events.
2. To learn that optimal prevention of radiation-induced major cardiac events requires early detection/imaging biomarkers.

09:13
09:18
The MEDIRAD Early-Heart study
S. Jacob; Fontenay aux Roses/FR
Learning Objectives

1. To appreciate that there is already some information from cardiac imaging studies regarding early cardiovascular effects after breast cancer radiotherapy.
2. To learn how the MEDIRAD Early-Heart study will provide information regarding imaging biomarkers of early cardiovascular effects after radiotherapy for breast cancer.
3. To understand that cardiac imaging can provide clues for underlying mechanisms of radiation-induced major cardiac events.

09:34
09:39
Imaging biomarkers of cardiovascular effects of low dose radiation
E. Mousseaux; Paris/FR
Learning Objectives

1. To appreciate how radiation-induced coronary artery lesions can be studied by cardiac CT.
2. To understand how MRI can be used to evaluate myocardial tissues abnormalities induced by incidental cardiac radiation, including morphology, function and tissue abnormalities.

09:55
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